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. 2008 Jan 10;358(2):199-200.
doi: 10.1056/NEJMc0707517.

Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis

Lisa R Young, Yoshikazu Inoue, Francis X McCormack

Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis

Lisa R Young et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Serum VEGF-D Levels in Patients with Lymphangioleiomyomatosis (LAM) as Compared with Healthy Controls and Patients with Other Diseases, and VEGF-D Levels in Women with the Tuberous Sclerosis Complex (TSC) and LAM as Compared with Women and Men with TSC Only
After receiving institutional-review-board approval, we obtained serum samples from 38 patients with LAM and 29 healthy controls (86% of whom were women) and evaluated them by means of an enzyme-linked immunosorbent assay (R&D Systems). Panel A shows VEGF-D levels in patients with LAM as compared with healthy controls and patients with other diseases. The group of patients with LAM consisted of 15 patients with biopsy-proven LAM and 23 with clinically definite LAM (17 had TSC, and 6 had cystic lung disease with angiomyolipomata, chylous manifestations, or both). The patients with LAM had a broad spectrum of disease severity, with 40% having mild disease, 31% moderate disease, and 29% severe obstruction on the basis of the forced expiratory volume in 1 second. Patients with other diseases included 7 patients with pulmonary Langerhans’-cell histiocytosis (PLCH) (43% were women), 7 with lymphangiomatosis (all were women), and 13 with emphysema (31% were women, and 38% had severe obstructive lung disease). Panel B shows serum VEGF-D levels in the 17 patients with TSC and LAM (all of whom were women) as compared with 12 women who had TSC only (with normal chest CT scans), and 14 men who had TSC only. In both panels, different intervals are shown above and below the hatch marks on the y axis; the horizontal lines indicate mean values.
See this image and copyright information in PMC

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