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. 2008 Jan 11:5:4.
doi: 10.1186/1743-422X-5-4.

Genetic analysis of hantaviruses carried by Myodes and Microtus rodents in Buryatia

Angelina Plyusnina  1 , Juha Laakkonen, Jukka Niemimaa, Kirill Nemirov, Galina Muruyeva, Boshikto Pohodiev, Ake Lundkvist, Antti Vaheri, Heikki Henttonen, Olli Vapalahti, Alexander Plyusnin
Affiliations

Genetic analysis of hantaviruses carried by Myodes and Microtus rodents in Buryatia

Angelina Plyusnina et al. Virol J. .

Abstract

Hantavirus genome sequences were recovered from tissue samples of Myodes rufocanus, Microtus fortis and Microtus oeconomus captured in the Baikal area of Buryatia, Russian Federation. Genetic analysis of S- and M-segment sequences of Buryatian hantavirus strains showed that Myodes-associated strains belong to Hokkaido virus (HOKV) type while Microtus-associated strains belong to Vladivostok virus (VLAV) type. On phylogenetic trees Buryatian HOKV strains were clustered together with M. rufocanus- originated strains from Japan, China and Far-East Russia (Primorsky region). Buryatian Microtus- originated strains shared a common recent ancestor with M. fortis- originated VLAV strain from Far-East Russia (Vladivostok area). Our data (i) confirm that M. rufocanus carries a hantavirus which is similar to but distinct from both Puumala virus carried by M. glareolus and Muju virus associated with M. regulus, (ii) confirm that M. fortis is the natural host for VLAV, and (iii) suggest M. oeconomus as an alternative host for VLAV.

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Figures

Figure 1
Figure 1
Phylogenetic tree (Fitch-Margoliash) of hantaviruses based on the complete coding region of the S segment. Only bootstrap support values greater than 70% are shown. HTNV, Hantaan virus, strain 76–118; DOBV, Dobrava virus (strain Slovenia); SAAV, Saaremaa virus, strain Saaremaa; SEOV, Seoul virus strain (R22); THAI, Thailand virus strain Thailand/Bi50); ANDV, Andes virus (strain Chile9717869); LANV, Laguna Negra virus (strain 510B); RIOMV, Rio Mamore virus (strain OM556); SNV, Sin Nombre virus (strain NMH10); NYV, New York virus (strain New York-1); MGLV, Monongahela virus (strain Monongahela1); RIOSV, Rio Segundo virus (strain RMx-Costa-1); ELMCV, El Moro Canyon virus (strain RM97); MULV, Muleshoe virus (strain SH-Tx-339); BCCV, Black Creek Canal virus; KHAV, Khabarovsk virus (strain MF43); TOPV, Topografov virus (strain TopografovLs136); VLAV, Vladivostok virus; PUUV, Puumala virus; HOKV, Hokkaido virus; MUJV, Muju virus; TULV, Tula virus (strain Moravia02); ISLAV, Isla Vista virus (strain MC-SB-47); PHV, Prospect Hill virus (strain PH1); BLLV, Blood Land Lake virus (strain Mo46).
Figure 2
Figure 2
Phylogenetic tree (Fitch-Margoliash) of Myodes-associated hantaviruses based on partial M segment sequence (nt 2702-3007). For abbreviations, see Fig. 1.
Figure 3
Figure 3
Phylogenetic tree (Fitch-Margoliash) of Microtus-associated hantaviruses based on partial M segment sequence (nt 2766-3007). For abbreviations, see Fig. 1.
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