Review
doi: 10.1016/j.cell.2007.12.017.
How IRE1 reacts to ER stress
Affiliations
- PMID: 18191217
- DOI: 10.1016/j.cell.2007.12.017
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Review
How IRE1 reacts to ER stress
Cell.
.
Free article
Abstract
The long-awaited structure of the effector portion of IRE1, the endoplasmic reticulum stress transducer, is published in this issue of Cell (Lee et al., 2008). This structure provides new insight into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserved branch of the unfolded protein response in eukaryotes.
Comment on
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Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing.Cell. 2008 Jan 11;132(1):89-100. doi: 10.1016/j.cell.2007.10.057. Cell. 2008. PMID: 18191223 Free PMC article.
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