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Comment
. 2008 Jan 17;3(1):5-6.
doi: 10.1016/j.chom.2007.12.004.

Beta2 integrin mediates entry of a bacterial toxin into T lymphocytes

Timothy L Cover  1
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Beta2 integrin mediates entry of a bacterial toxin into T lymphocytes

Timothy L Cover. Cell Host Microbe. .
Free article

Abstract

Helicobacter pylori secretes a pore-forming toxin, VacA, that can cause numerous alterations in gastric epithelial cells and T lymphocytes. In this issue of Cell Host & Microbe, Sewald and colleagues report that beta2 integrin (CD18) mediates entry of VacA into human T cells. Downregulation of T cell responses by VacA may allow H. pylori to evade the adaptive immune response and establish persistent infection.

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