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Comparative Study
. 2008 Feb;40(2):149-51.
doi: 10.1038/ng.2007.61. Epub 2008 Jan 13.

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

Jaspal S Kooner  1 , John C Chambers, Carlos A Aguilar-Salinas, David A Hinds, Craig L Hyde, Gregory R Warnes, Francisco J Gómez Pérez, Kelly A Frazer, Paul Elliott, James Scott, Patrice M Milos, David R Cox, John F Thompson
Affiliations
Comparative Study

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

Jaspal S Kooner et al. Nat Genet. 2008 Feb.

Abstract

We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'.

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