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Review
. 2008 Mar;65(5):672-86.
doi: 10.1007/s00018-007-7484-1.

Structures of thrombospondins

C B Carlson  1 , J Lawler, D F Mosher
Affiliations
Review

Structures of thrombospondins

C B Carlson et al. Cell Mol Life Sci. 2008 Mar.

Abstract

Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review).

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