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Comment
. 2008 Feb;73(3):251-3.
doi: 10.1038/sj.ki.5002695.

Calcium, cyclic AMP, and MAP kinases: dysregulation in polycystic kidney disease

B D Cowley Jr  1
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Free article
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Calcium, cyclic AMP, and MAP kinases: dysregulation in polycystic kidney disease

B D Cowley Jr. Kidney Int. 2008 Feb.
Free article

Abstract

Low intracellular calcium, present in untreated polycystic kidney epithelia, results in a proliferative response to cyclic adenosine monophosphate. Treatment with a calcium channel blocker (CCB) caused exacerbation of autosomal dominant polycystic kidney disease in rats. Data regarding use of CCBs in human polycystic kidney disease (PKD) are limited and mixed. Thus, it is premature to extrapolate these findings to human PKD.

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