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. 2008 Mar;466(3):729-36.
doi: 10.1007/s11999-007-0051-0. Epub 2008 Jan 3.

Predictors of survival in patients with bone metastasis of lung cancer

Hideshi Sugiura  1 , Kenji Yamada, Takahiko Sugiura, Toyoaki Hida, Tetsuya Mitsudomi
Affiliations

Predictors of survival in patients with bone metastasis of lung cancer

Hideshi Sugiura et al. Clin Orthop Relat Res. 2008 Mar.

Abstract

The prognosis of patients with bone metastasis from lung cancer has not been well documented. We assessed the survival rates after bone metastasis and prognostic factors in 118 patients with bone metastases from lung cancer. The cumulative survival rates after bone metastasis from lung cancer were 59.9% at 6 months, 31.6% at 1 year, and 11.3% at 2 years. The mean survival was 9.7 months (median, 7.2 months; range, 0.1-74.5 months). A favorable prognosis was more likely in women and patients with adenocarcinoma, solitary bone metastasis, no metastases to the appendicular bone, no pathologic fractures, performance status 1 or less, use of systemic chemotherapy, and use of an epithelial growth factor receptor inhibitor. Analyses of single and multiple variables indicated better prognoses for patients with adenocarcinoma, no evidence of appendicular bone metastases, and treatment with an epithelial growth factor receptor inhibitor. The mean survival period was longer in a small group treated with an epithelial growth factor receptor inhibitor than in the larger untreated group. The data preliminarily suggest treatment with an epithelial growth factor receptor inhibitor may improve survival after bone metastasis.

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Figures

Fig. 1
Fig. 1
Anatomic localization of skeletal metastases from lung cancer is shown (n = 118).
Fig. 2
Fig. 2
A Kaplan–Meier curve of overall survival for all patients is illustrated. The dotted lines indicate the 95% confidence interval. The overall cumulative survival rates after bone metastasis for all 118 patients are 59.9% for 6 months, 31.6% for 1 year, and 11.3% for 2 years.
Fig. 3
Fig. 3
A Kaplan–Meier curve of overall survival based on absence or presence of metastasis of the appendicular bone is illustrated. The dotted lines indicate the 95% confidence interval. The prognosis is poorer (p = 0.03) in patients with metastasis to the appendicular bone than in patients without metastasis.
Fig. 4
Fig. 4
A Kaplan–Meier curve of overall survival based on absence or presence of gefitinib treatment is illustrated. The dotted lines indicate the 95% confidence interval. The mean survival is longer (p = 0.005) in the group treated with gefitinib than in the untreated group among 52 patients with adenocarcinoma and PS 1 or less.
See this image and copyright information in PMC

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