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Review
. 2008 Jan;28(1):1-4.
doi: 10.1016/j.immuni.2007.12.008.

Genetic background and the dilemma of translating mouse studies to humans

Juan Rivera  1 , Lino Tessarollo
Affiliations
Free article
Review

Genetic background and the dilemma of translating mouse studies to humans

Juan Rivera et al. Immunity. 2008 Jan.
Free article

Abstract

C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.

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