Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore
- PMID: 18199410
- DOI: 10.1016/j.immuni.2007.12.006
Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore
Abstract
T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation.
Comment on
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T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.Immunity. 2008 Jan;28(1):29-39. doi: 10.1016/j.immuni.2007.11.016. Epub 2007 Dec 27. Immunity. 2008. PMID: 18164222 Free PMC article.
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