Understanding lupus: fishing genes out of mice and men
- PMID: 18199411
- DOI: 10.1016/j.immuni.2007.12.007
Understanding lupus: fishing genes out of mice and men
Abstract
In this issue of Immunity, the Coronin-1A gene Coro1a, which regulates cytoskeletal structure, is shown by Haraldsson et al. (2007) to be a surprising disease-susceptibility gene that contributes to the spontaneous systemic autoimmunity in the MRL mouse, a model of systemic lupus erythematosus.
Comment on
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The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.Immunity. 2008 Jan;28(1):40-51. doi: 10.1016/j.immuni.2007.11.023. Immunity. 2008. PMID: 18199416 Free PMC article.
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