Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2008 Mar;3(2):637-45.
doi: 10.2215/CJN.05071107. Epub 2008 Jan 16.

A case of treated ANCA-associated vasculitis with recurrent renal failure

Alan D Salama  1 , H Terence Cook, Charles D Pusey, Ruth J Pepper
Affiliations
Case Reports

A case of treated ANCA-associated vasculitis with recurrent renal failure

Alan D Salama et al. Clin J Am Soc Nephrol. 2008 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Chest radiograph upon first presentation demonstrating ill-defined areas of airspace shadowing both in lung fields particularly in the right midzone and at the right base. No obvious cavitation is seen.
Figure 2.
Figure 2.
High-resolution CT scan upon first presentation demonstrating nonuniform areas of airspace shadowing and consolidation in both lung fields, more so on the right. There are subsegmental areas of consolidation with some volume loss in the right upper and middle lobes. Air bronchograms are evident. No cavitation is present.
Figure 3.
Figure 3.
All of the glomeruli in the biopsy showed fibrinoid necrosis (A and B; hematoxylin and eosin [H&E]). In some, there were early lesions with segmental fibrinoid necrosis, while many have large cellular crescents (C and D; Jones methenamine silver) with rupture of Bowman’s capsule in some (D).
Figure 4.
Figure 4.
Graph demonstrating the response to treatment of serum creatinine, CRP, and PR3-ANCA in our patient over time. The downward arrow demonstrates the time when azathioprine was introduced.
Figure 5.
Figure 5.
Chest radiograph upon re-presentation in June, demonstrating significant improvement in the overall appearances but with some residual scarring in the right lung field.
Figure 6.
Figure 6.
Low-power view of the renal cortex shows prominent foci of interstitial expansion with inflammatory cell infiltration (H&E).
Figure 7.
Figure 7.
At high power, the inflammatory infiltrate is seen to contain many neutrophils with prominent tubulitis (H&E)
Figure 8.
Figure 8.
Glomeruli showed segmental scars, but no necrosis was seen (H&E).
See this image and copyright information in PMC

References

    1. Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CG, et al. : Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 37: 187–192, 1994 - PubMed
    1. Walton EW: Giant-cell granuloma of the respiratory tract (Wegener’s granulomatosis). BMJ 2: 265–270, 1958 - PMC - PubMed
    1. Fauci AS, Haynes BF, Katz P, Wolff SM: Wegener’s granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 98: 76–85, 1983 - PubMed
    1. Booth AD, Almond MK, Burns A, Ellis P, Gaskin G, Neild GH, Plaisance M, Pusey CD, Jayne DR: Outcome of ANCA-associated renal vasculitis: A 5-year retrospective study. Am J Kidney Dis 41: 776–784, 2003 - PubMed
    1. Harper L, Savage CO: ANCA-associated renal vasculitis at the end of the twentieth century: A disease of older patients. Rheumatology (Oxford) 44: 495–501, 2005 - PubMed

Publication types

Substances