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Review
. 2008 Jan 21;14(3):338-47.
doi: 10.3748/wjg.14.338.

Inflammatory bowel disease: genetic and epidemiologic considerations

Judy H Cho  1
Affiliations
Review

Inflammatory bowel disease: genetic and epidemiologic considerations

Judy H Cho. World J Gastroenterol. .

Abstract

Genome-wide association studies have firmly established that many genomic loci contribute to inflammatory bowel disease, especially in Crohn's disease. These studies have newly-established the importance of the interleukin 23 and autophagy pathways in disease pathogenesis. Future challenges include: (1) the establishment of precisely causal alleles, (2) definition of altered functional outcomes of associated and causal alleles and (3) integration of genetic findings with environmental factors.

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References

    1. Halfvarson J, Bodin L, Tysk C, Lindberg E, Jarnerot G. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology. 2003;124:1767–1773. - PubMed
    1. Orholm M, Binder V, Sorensen TI, Rasmussen LP, Kyvik KO. Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study. Scand J Gastroenterol. 2000;35:1075–1081. - PubMed
    1. Thompson NP, Driscoll R, Pounder RE, Wakefield AJ. Genetics versus environment in inflammatory bowel disease: results of a British twin study. BMJ. 1996;312:95–96. - PMC - PubMed
    1. Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B. Ulcerative colitis and Crohn’s disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut. 1988;29:990–996. - PMC - PubMed
    1. Binder V. Genetic epidemiology in inflammatory bowel disease. Dig Dis. 1998;16:351–355. - PubMed

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