Viruses associated with human cancer

Abstract

It is estimated that viral infections contribute to 15-20% of all human cancers. As obligatory intracellular parasites, viruses encode proteins that reprogram host cellular signaling pathways that control proliferation, differentiation, cell death, genomic integrity, and recognition by the immune system. These cellular processes are governed by complex and redundant regulatory networks and are surveyed by sentinel mechanisms that ensure that aberrant cells are removed from the proliferative pool. Given that the genome size of a virus is highly restricted to ensure packaging within an infectious structure, viruses must target cellular regulatory nodes with limited redundancy and need to inactivate surveillance mechanisms that would normally recognize and extinguish such abnormal cells. In many cases, key proteins in these same regulatory networks are subject to mutation in non-virally associated diseases and cancers. Oncogenic viruses have thus served as important experimental models to identify and molecularly investigate such cellular networks. These include the discovery of oncogenes and tumor suppressors, identification of regulatory networks that are critical for maintenance of genomic integrity, and processes that govern immune surveillance.

Figure 1

Schematic depiction of the major biological activities that contribute to the transforming activities of HTLV-1. See text for details.

Figure 2

Schematic depiction of the major biological activities that contribute to the transforming activities of HCV. See text for details.

Figure 3

Schematic depiction of the major biological activities that contribute to the transforming activities of high-risk mucosal HPVs. See text for details.

Figure 4

Schematic depiction of the major biological activities that contribute to the transforming activities of HBV. See text for details.

Figure 5

Schematic depiction of the major biological activities that contribute to the transforming activities of EBV. See text for details.

Figure 6

Schematic depiction of the major biological activities that contribute to the transforming activities of HHV-8/KSHV. See text for details.