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Review
. 2008 Jul;90(1):105-12.
doi: 10.1016/j.pbb.2007.12.011. Epub 2008 Jan 16.

GABA(A) receptor subtypes underlying general anesthesia

Robert P Bonin  1 , Beverley A Orser
Affiliations
Review

GABA(A) receptor subtypes underlying general anesthesia

Robert P Bonin et al. Pharmacol Biochem Behav. 2008 Jul.

Abstract

General anesthetics produce a constellation of behavioral responses and widespread neurodepression. Recent studies have implicated the gamma-aminobutyric acid (GABA) subtype A receptor as a primary anesthetic target. During the past decade, considerable progress has been made in dissecting the behavioral effects of anesthetics according to the subunit composition of GABA(A) receptors. In this review, we describe how particular GABA(A) receptor subtypes expressed in different brain regions are critical for the expression of behavioral endpoints, such as amnesia, sedation, and hypnosis.

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