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Meta-Analysis
. 2008 Feb;40(2):152-4.
doi: 10.1038/ng.71. Epub 2008 Jan 20.

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus

Swapan K Nath  1 , Shizhong Han, Xana Kim-Howard, Jennifer A Kelly, Parvathi Viswanathan, Gary S Gilkeson, Wei Chen, Cheng Zhu, Rodger P McEver, Robert P Kimberly, Marta E Alarcón-Riquelme, Timothy J Vyse, Quan-Zhen Li, Edward K Wakeland, Joan T Merrill, Judith A James, Kenneth M Kaufman, Joel M Guthridge, John B Harley
Affiliations
Meta-Analysis

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus

Swapan K Nath et al. Nat Genet. 2008 Feb.

Abstract

We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.

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