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. 2008 Jul 5;147B(5):667-8.
doi: 10.1002/ajmg.b.30658.

Failure to replicate effect of Kibra on human memory in two large cohorts of European origin

Anna C Need  1 , Deborah K Attix, Jill M McEvoy, Elizabeth T Cirulli, Kristen N Linney, Ana Patricia Wagoner, Curtis E Gumbs, Ina Giegling, Hans-Jürgen Möller, Clyde Francks, Pierandrea Muglia, Allen Roses, Greg Gibson, Mike E Weale, Dan Rujescu, David B Goldstein
Affiliations

Failure to replicate effect of Kibra on human memory in two large cohorts of European origin

Anna C Need et al. Am J Med Genet B Neuropsychiatr Genet. .

Abstract

It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.

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