Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Mar;58(3):458-71.
doi: 10.1016/j.jaad.2007.12.006. Epub 2008 Jan 18.

Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B

Roger H Weenig  1
Affiliations
Review

Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B

Roger H Weenig. J Am Acad Dermatol. 2008 Mar.

Abstract

The clinical syndrome of calciphylaxis is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, necrotic skin ulceration, and a high mortality rate. This review integrates calciphylaxis risk factors with the molecular processes governing osseous and extraosseous mineralization. As the pathogenesis of calciphylaxis is better understood, targeted therapies aimed at disease prevention and reversal will follow.

PubMed Disclaimer

Personal name as subject