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. 2008 Mar;195(3):358-61; discussion 361-2.
doi: 10.1016/j.amjsurg.2007.11.008.

Predicting cancer on excision of atypical ductal hyperplasia

Erin Doren  1 , Melissa Hulvat, Jonathan Norton, Prabha Rajan, Sharfi Sarker, Gerard Aranha, Katharine Yao
Affiliations

Predicting cancer on excision of atypical ductal hyperplasia

Erin Doren et al. Am J Surg. 2008 Mar.

Abstract

Background: There are no specific histopathologic factors that allow identification of patients with atypical ductal hyperplasia (ADH) who will have cancer on final excision.

Methods: This was a retrospective study of all patients who had ADH on biopsy followed by excision from 1999 to 2006.

Results: Fifty-one patients were found to have ADH on core biopsy. Eight (15.7%) patients had invasive carcinoma on surgical excision, 9 (17.5%) had ductal carcinoma-in-situ (DCIS), 21 (41.5%) had ADH, 4 (8%) patients had atypical lobular hyperplasia, and 9 (17.5%) had benign tumors. The grade of atypia on the core biopsy was mild in 13 (25%) patients, moderate in 22 (43%), and marked in 16 (32%). On multivariate analysis of histopathologic factors, the grade of atypia was the only significant variable that predicted a diagnosis of cancer on final surgical excision (P = .001).

Conclusions: The grade of atypia correlated with the presence of cancer on surgical excision.

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