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Review
. 2008 Jan 18;29(1):1-7.
doi: 10.1016/j.molcel.2007.12.010.

Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs

Ligang Wu  1 , Joel G Belasco
Affiliations
Free article
Review

Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs

Ligang Wu et al. Mol Cell. .
Free article

Abstract

The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.

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