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Comparative Study
. 1991:Spec No 3:371-8.

Dissolution kinetics of bezafibrate in two solid forms for oral administration

R Cadorniga  1 , M T Hernanez, S Negro, M L Burgos, I T Molina
Affiliations
  • PMID: 1820910
Comparative Study

Dissolution kinetics of bezafibrate in two solid forms for oral administration

R Cadorniga et al. Eur J Drug Metab Pharmacokinet. 1991.

Abstract

The dissolution kinetics of two solid and oral formulations of bezafibrate have been studied. These preparations are available in the Spanish market. Both of them are tablets, one conventional-release (A) and the other slow-release formulation (C). Dissolution studies have been performed using the system proposed by the USP XXI. The solubility of the drug was determined in each release medium at 37 degrees C. The results indicate that the sink conditions were not satisfied. The evaluation of the dissolution rate-kinetics is performed by three different mathematical approaches. Strong differences in its "in vitro" behaviour were found.

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