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. 2008 Jan;22(1):110-7.
doi: 10.1037/0894-4105.22.1.110.

HIV-associated prospective memory impairment increases risk of dependence in everyday functioning

Steven Paul Woods  1 , Jennifer E Iudicello, Lisa M Moran, Catherine L Carey, Matthew S Dawson, Igor Grant; HIV Neurobehavioral Research Center Group
Affiliations

HIV-associated prospective memory impairment increases risk of dependence in everyday functioning

Steven Paul Woods et al. Neuropsychology. 2008 Jan.

Abstract

HIV infection is associated with impairments in prospective memory (ProM), an aspect of episodic memory that refers to the ability to execute a future intention, such as remembering to take a medication at a specific time. The current study sought to examine the relationship between HIV-associated ProM impairment and the successful management of instrumental activities of daily living (IADLs). In a cohort of 66 HIV-infected individuals, ProM accounted for a significant proportion of variance in self-reported IADL dependence, over and above that which was explained by retrospective memory and by current affective distress. Analysis of component cognitive processes revealed that the relationship between HIV-associated ProM deficits and IADL dependence was driven by impaired cue detection and by deficits in self-initiated intention retrieval. Results were not better explained by demographic factors, HIV disease severity, psychiatric comorbidity, or substance use. Collectively, these data support the potential incremental ecological validity of ProM as a predictor of dependence in IADLs among persons living with HIV infection.

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