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. 2008 Feb;92(2):179-81.
doi: 10.1136/bjo.2007.127050. Epub 2008 Jan 22.

HLA-DR17 and Mooren's ulcer in South India

J R Zelefsky  1 , C J Taylor, M Srinivasan, S Peacock, R S Goodman, T Key, P G Watson, E T Cunningham
Affiliations

HLA-DR17 and Mooren's ulcer in South India

J R Zelefsky et al. Br J Ophthalmol. 2008 Feb.

Abstract

Objective: To investigate the association between Mooren's ulcer and human leucocyte antigen (HLA) type DR17(3) in patients from the Tamil Nadu State of South India.

Methods: Blood samples from 38 patients with Mooren's ulcer and 45 age- and sex-matched controls were obtained prospectively. HLA-DR and HLA-DQ typing was performed by PCR using sequence-specific primers.

Results: Fifteen (40%) of the patients with Mooren's ulcer tested positive for HLA-DR17(3) compared with seven (16%) of the controls (p = 0.01). Seventeen (45%) of the patients also tested positive for the closely linked HLA-DQ2 compared with 11 (24%) of controls (p = 0.05). When adjusted for multiplicity, the correlation between HLA-DR17(3) and Mooren's ulcer remained significant (p = 0.03).

Conclusions: These data demonstrate an association between HLA-DR17(3) and Mooren's ulcer in South Indian patients, supporting autoimmune theories about the pathogenesis of the disorder.

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