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. 2008 Apr;52(4):1570-2.
doi: 10.1128/AAC.01098-07. Epub 2008 Jan 22.

Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances

Silke Besier  1 , Albrecht Ludwig, Johannes Zander, Volker Brade, Thomas A Wichelhaus
Affiliations

Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances

Silke Besier et al. Antimicrob Agents Chemother. 2008 Apr.

Abstract

Linezolid resistance in Staphylococcus aureus is typically associated with mutations in the 23S rRNA gene. Here we show that the accumulation of a single point mutation, G2576T, in the different copies of this gene causes stepwise increases in resistance, impairment of the biological fitness, and cross-resistance to quinupristin-dalfopristin and chloramphenicol.

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Figures

FIG. 1.
FIG. 1.
Growth kinetics of S. aureus strain T991 and its descendants T1887, T1888, T1900, T1910, and T2019. Data are expressed as the means ± standard deviations of the results of three experiments.
See this image and copyright information in PMC

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