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Clinical Trial
. 1991 Summer;3(3):314-9.
doi: 10.1176/jnp.3.3.314.

The relationship of serum anticholinergic activity to mental status performance in an elderly nursing home population

G D Tollefson  1 , J Montague-Clouse, S P Lancaster
Affiliations
Clinical Trial

The relationship of serum anticholinergic activity to mental status performance in an elderly nursing home population

G D Tollefson et al. J Neuropsychiatry Clin Neurosci. 1991 Summer.

Abstract

Adverse drug reactions among elderly patients pose a significant clinical problem. The authors used a serum radioreceptor assay [RRA] to quantify drug-induced muscarinic blockade in 34 randomly selected nursing home residents. A random intervention group and the nonintervention control subjects were then retested 4 weeks later. The reduction of serum antimuscarinic activity (as determined by RRA) did relate to changes on several measures of cognitive function. A calculated "antimuscarinic index" lost significance with the RRA following intervention and may have overestimated the impact of a dosage reduction.

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