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Review
. 2008 Feb;67(1):59-61.
doi: 10.1007/s00393-008-0261-1.

[Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients]

[Article in German]
W K Aicher  1 , T Pap, S Gay
Affiliations
Review

[Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients]

[Article in German]
W K Aicher et al. Z Rheumatol. 2008 Feb.

Abstract

Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.

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References

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    1. Arthritis Res. 2000;2(5):361-7 - PubMed
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    1. Arthritis Rheum. 2004 Aug;50(8):2381-6 - PubMed
    1. Front Biosci. 2006 Jan 01;11:529-43 - PubMed

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