Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Apr;15(4):956-60.
doi: 10.1245/s10434-007-9798-5. Epub 2008 Jan 23.

More controversy than ever - challenges and promises towards personalized treatment of gastric cancer

Affiliations
Review

More controversy than ever - challenges and promises towards personalized treatment of gastric cancer

Theodore Liakakos et al. Ann Surg Oncol. 2008 Apr.
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Flow chart for decision-making regarding adjuvant treatment for resectable gastric cancer. aD2 surgery if surgeon’s experience ensures a safe and effective procedure. If a standardized D2 surgery is not feasible, D1 surgery with chemoradiotherapy or preoperative chemotherapy can be considered. bAdjuvant treatment: Cisplatin-based chemotherapy for Western patients, S-1 chemotherapy for East Asian patients. Addition of targeted agents to empirical chemotherapy only in randomized trials. RCTs: randomized controlled trials.

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1056/NEJMoa072252', 'is_inner': False, 'url': 'https://doi.org/10.1056/nejmoa072252'}, {'type': 'PubMed', 'value': '17978289', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/17978289/'}]}
    2. Sakuramoto S, Sasako M, Yamaguchi T, et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 2007;357:1810–20 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1056/NEJMoa055531', 'is_inner': False, 'url': 'https://doi.org/10.1056/nejmoa055531'}, {'type': 'PubMed', 'value': '16822992', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16822992/'}]}
    2. Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355:11–20 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1056/NEJMoa010187', 'is_inner': False, 'url': 'https://doi.org/10.1056/nejmoa010187'}, {'type': 'PubMed', 'value': '11547741', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11547741/'}]}
    2. Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001;345:725–730 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/j.cell.2007.01.007', 'is_inner': False, 'url': 'https://doi.org/10.1016/j.cell.2007.01.007'}, {'type': 'PubMed', 'value': '17254958', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/17254958/'}]}
    2. Friedman A, Perrimon N. Genetic screening for signal transduction in the era of network biology. Cell 2007;128:225–31 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1038/nrc1976', 'is_inner': False, 'url': 'https://doi.org/10.1038/nrc1976'}, {'type': 'PubMed', 'value': '16915294', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16915294/'}]}
    2. Bild AH, Potti A, Nevins JR. Linking oncogenic pathways with therapeutic opportunities. Nature Rev Canc 2006;6:735–41 - PubMed

Substances