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. 1976 Jun 15;156(3):685-9.
doi: 10.1042/bj1560685.

Effect of haematocrit value and pO2 on the redox state and metabolism of the perfused liver

P A Mayes, J M Felts

Effect of haematocrit value and pO2 on the redox state and metabolism of the perfused liver

P A Mayes et al. Biochem J. .

Abstract

1. The haematocrit value and pO2 of blood perfusing the isolated liver were varied. Provided O2 content of the blood was not rate-limiting, O2 consumption was related to haemotocrit value rather than O2 saturation or pO2. 2. Hypoxia caused the blood-glucose concentration and ketogenesis to increase and the output of very-low-density (d less than 1.006) lipoproteins to decrease. 3. A decrease in pO2 caused an increase in both the (lactate)/(pyruvate) and (3-hydroxybutyrate)/(acetoacetate) and a decrease in (ATP)/(ADP) ratios, independently of O2 consumption. 4. The more reduced redox state was associated with a shift in the balance between the oxidation and esterification of free fatty acids in favour of oxidation. 5. Acetoacetate may be an important hydrogen acceptor during hypoxia of the liver.

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