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Case Reports
. 2008 Jan 24;358(4):362-8.
doi: 10.1056/NEJMoa074191.

Tolerance and chimerism after renal and hematopoietic-cell transplantation

John D Scandling  1 , Stephan Busque, Sussan Dejbakhsh-Jones, Claudia Benike, Maria T Millan, Judith A Shizuru, Richard T Hoppe, Robert Lowsky, Edgar G Engleman, Samuel Strober
Affiliations
Free article
Case Reports

Tolerance and chimerism after renal and hematopoietic-cell transplantation

John D Scandling et al. N Engl J Med. .
Free article

Abstract

We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient had persistent mixed chimerism, and the function of the kidney allograft has been normal for more than 28 months since discontinuation of all immunosuppressive drugs. Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease.

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