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Comparative Study
. 2008 May;61(1):76-9.
doi: 10.1016/j.diagmicrobio.2007.12.010. Epub 2008 Jan 24.

In vitro potency evaluations of various piperacillin/tazobactam generic products compared with the contemporary branded (Zosyn, Wyeth) formulation

Ronald N Jones  1 , Thomas R Fritsche, Gary J Moet
Affiliations
Comparative Study

In vitro potency evaluations of various piperacillin/tazobactam generic products compared with the contemporary branded (Zosyn, Wyeth) formulation

Ronald N Jones et al. Diagn Microbiol Infect Dis. 2008 May.

Erratum in

  • Diagn Microbiol Infect Dis. 2008 Jul;61(3):366-8

Abstract

Twenty-three generic intravenous piperacillin/tazobactam products were compared for in vitro activity to the branded formulation (Zosyn, Wyeth, Philadelphia, PA) by disk diffusion and incremental broth microdilution assay methods. All but 1 lot demonstrated significantly decreased activity (-5 to -35%), necessitating further investigations regarding the chemical purity, potency, and therapeutic equivalence of these products worldwide. The average -16% activity across all generic lots was equivalent to underdosing piperacillin/tazobactam by 2.6 g daily for serious clinical infections (4.5 g Q6 h).

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