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Multicenter Study
. 2008 Feb;44(3):465-71.
doi: 10.1016/j.ejca.2007.12.009. Epub 2008 Jan 24.

A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma

Christian C Abnet  1 , Neal D Freedman, Albert R Hollenbeck, Joseph F Fraumeni Jr, Michael Leitzmann, Arthur Schatzkin
Affiliations
Multicenter Study

A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma

Christian C Abnet et al. Eur J Cancer. 2008 Feb.

Abstract

The incidence of oesophageal adenocarcinoma (EADC) is rapidly increasing in Western countries and obesity is thought to be a major risk factor. We examined the association between BMI and EADC, gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma in a cohort of approximately 500,000 people in the United States (US). We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) with control for many potential confounders. We found that compared to people with a BMI of 18.5-25kg/m2, a BMI > or = 35 was associated with significantly increased risk of EADC, HR (95% CI)=2.27 (1.44-3.59) and gastric cardia adenocarcinoma 2.46 (1.60-3.80), but not gastric non-cardia adenocarcinoma 0.84 (0.50-1.42). Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI. Increased adiposity was associated with higher risk of EADC even within the normal weight range.

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Conflict of interest statement

Conflict of interest statement: None declared

Figures

Figure 1
Figure 1. Non-linear associations between current BMI and odds of upper gastrointestinal adenocarcinomas in the NIH-AARP Diet and Health study
The associations between current BMI and odds of upper gastrointestinal adenocarcinomas are plotted on the logit scale. The point estimates are plotted using black circles and the 95% confidence intervals are plotted using grey triangles. The vertical dotted lines demarcate the bounds used in the categorical analysis.
See this image and copyright information in PMC

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