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. 2008 Mar;198(3):279.e1-8.
doi: 10.1016/j.ajog.2007.10.803. Epub 2008 Jan 25.

Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study

Xiaoping Weng  1 , Roxana Odouli, De-Kun Li
Affiliations

Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study

Xiaoping Weng et al. Am J Obstet Gynecol. 2008 Mar.

Abstract

Objective: The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms.

Study design: This was a population-based prospective cohort study.

Results: An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94).

Conclusion: Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.

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Comment in

  • Maternal caffeine consumption during pregnancy and the risk of miscarriage.
    Armstrong E, Harris LH, Kukla R, Kuppermenn M, Little MO, Lyerly AD, Mitchell LM; Obstetrics and Gynecology Risk Research Group. Armstrong E, et al. Am J Obstet Gynecol. 2008 Nov;199(5):e13; author reply e13-4. doi: 10.1016/j.ajog.2008.05.031. Epub 2008 Jul 29. Am J Obstet Gynecol. 2008. PMID: 18667176 No abstract available.
  • Caffeine and miscarriage: case closed?
    Signorello LB, McLaughlin JK. Signorello LB, et al. Am J Obstet Gynecol. 2008 Nov;199(5):e14-5. doi: 10.1016/j.ajog.2008.05.033. Epub 2008 Jul 29. Am J Obstet Gynecol. 2008. PMID: 18667179 No abstract available.
  • Is caffeine use during pregnancy really unsafe?
    Lynch CD, Klebanoff MA, Louis GM. Lynch CD, et al. Am J Obstet Gynecol. 2008 Nov;199(5):e16. doi: 10.1016/j.ajog.2008.05.035. Epub 2008 Aug 8. Am J Obstet Gynecol. 2008. PMID: 18691688 Free PMC article. No abstract available.
  • Caffeine in miscarriages: it's not just in the coffee.
    Graham NA, Hammond CJ 3rd, Gold MS. Graham NA, et al. Am J Obstet Gynecol. 2008 Nov;199(5):e15. doi: 10.1016/j.ajog.2008.05.034. Am J Obstet Gynecol. 2008. PMID: 18984072 No abstract available.

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