Surprises of the genome and "personalized" medicine

Editorial

Ali J Marian. J Am Coll Cardiol. 2008.

. 2008 Jan 29;51(4):456-8.

doi: 10.1016/j.jacc.2007.10.020.

No abstract available

Figures

Association of the 719Arg variant of KIF6 with both increased risk of coronary events and with greater response to statin therapy.
Iakoubova O, Shepherd J, Sacks F. Iakoubova O, et al. J Am Coll Cardiol. 2008 Jun 3;51(22):2195; author reply 2195-6. doi: 10.1016/j.jacc.2008.02.061. J Am Coll Cardiol. 2008. PMID: 18510970 No abstract available.

Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM. Iakoubova OA, et al. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. doi: 10.1016/j.jacc.2007.05.057. J Am Coll Cardiol. 2008. PMID: 18222353
A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.
Shiffman D, Chasman DI, Zee RY, Iakoubova OA, Louie JZ, Devlin JJ, Ridker PM. Shiffman D, et al. J Am Coll Cardiol. 2008 Jan 29;51(4):444-8. doi: 10.1016/j.jacc.2007.09.044. J Am Coll Cardiol. 2008. PMID: 18222354
Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.
Iakoubova OA, Sabatine MS, Rowland CM, Tong CH, Catanese JJ, Ranade K, Simonsen KL, Kirchgessner TG, Cannon CP, Devlin JJ, Braunwald E. Iakoubova OA, et al. J Am Coll Cardiol. 2008 Jan 29;51(4):449-55. doi: 10.1016/j.jacc.2007.10.017. J Am Coll Cardiol. 2008. PMID: 18222355 Clinical Trial.

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