Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Apr;8(2):147-52.
doi: 10.1016/j.coph.2007.12.005. Epub 2008 Jan 28.

Aptamers as candidate therapeutics for cardiovascular indications

Anthony D Keefe  1 , Robert G Schaub
Affiliations
Review

Aptamers as candidate therapeutics for cardiovascular indications

Anthony D Keefe et al. Curr Opin Pharmacol. 2008 Apr.

Abstract

The first therapeutic aptamer was approved for human use in 2004, and a range of chemical substitutions that improve the drug-like properties of aptamers has recently been shown to increase the utility of this modality. Currently there are both anticoagulant and antithrombotic aptamers in the clinic, and additionally there are a number of earlier stage projects in which a variety of cardiovascular targets are inhibited by specific aptamers and for which a wide range of therapeutic applications has been suggested.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources