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Review
. 2007;2(4):509-19.
doi: 10.2147/cia.s382.

Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers

Paul C Edwards  1 , John E Fantasia
Affiliations
Review

Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers

Paul C Edwards et al. Clin Interv Aging. 2007.

Abstract

Although only recently introduced, chemically-modified hyaluronic acid dermal fillers have gained widespread acceptance as "redefining" dermal fillers in the fields of dermatology and cosmetic facial surgery. Although hyaluronic acid-based dermal fillers have a low overall incidence of long-term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented. These long-term adverse events are reviewed.

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Figures

Figure 1
Figure 1
Low power view of biopsy specimen from lower lip from a 74-year-old woman who presented with a submucosal nodule of the lower lip. The patient had received injections of Restylane to the lips approximately 6 months before. Histologic examination of the biopsied specimen revealed the presence of multiple vacuolated, cyst-like areas. These are surrounded by a fibrotic connective tissue capsule and a tissue reaction composed predominantly of histiocytes and foamy macrophages. (Hematoxylin and eosin, original magnification 10×).
Figure 2
Figure 2
High power view of biopsy specimen from lower lip. Fibrotic tissue and abundant histiocytes surround the vacuolated areas. (Hematoxylin and eosin, original magnification 40×).
Figure 3
Figure 3
High power view of biopsy specimen from lower lip. A multinucleated foreign body-type giant cell is visible in the center of the photomicrograph. (Hematoxylin and eosin, original magnification 60×).
See this image and copyright information in PMC

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