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. 2008 Feb;198(2):216.e1-5.
doi: 10.1016/j.ajog.2007.08.028.

Prognostic factors and risk of extrauterine metastases in 3867 women with grade 1 endometrioid corpus cancer

John K Chan  1 , Daniel S Kapp, Michael K Cheung, Jacob Y Shin, Deirdre Stieglitz, Amreen Husain, Nelson N Teng, Jonathan S Berek, Kathryn Osann, Hongyan Guo
Affiliations

Prognostic factors and risk of extrauterine metastases in 3867 women with grade 1 endometrioid corpus cancer

John K Chan et al. Am J Obstet Gynecol. 2008 Feb.

Abstract

Objective: The purpose of this study was to evaluate the role of surgical staging in patients with grade 1 endometrioid uterine cancer.

Study design: Data were extracted from Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Kaplan-Meier and Cox proportional hazards analyses were used to determine predictors for disease-specific survival.

Results: Twelve thousand seven hundred and twelve women were reported with endometrioid carcinoma, including 3867 with grade 1 disease, of which 25.5% had stage IC or more advanced disease, 15.4% with disease extending beyond the uterine corpus, 7.3% with extrauterine metastases, and 3.3% with lymph node metastases. On multivariate analysis, younger age and earlier stage remained as significant prognostic factors for improved survival.

Conclusion: Since grade 1 endometrioid uterine cancers have a 15.4% risk of extrauterine spread, a complete surgical staging procedure is recommended when clinically feasible. Younger age and earlier stage are significant prognostic factors for improved survival.

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