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Review
. 2008 Mar;37(1):135-49, ix.
doi: 10.1016/j.ecl.2007.10.010.

Cushing's Syndrome

Rosario Pivonello  1 , Maria Cristina De Martino, Monica De Leo, Gaetano Lombardi, Annamaria Colao
Affiliations
Review

Cushing's Syndrome

Rosario Pivonello et al. Endocrinol Metab Clin North Am. 2008 Mar.

Abstract

Cushing's syndrome is a rare endocrine disease characterized by cortisol hypersecretion, induced mainly by a pituitary tumor (Cushing's disease) or, rarely, by an adrenal or an ectopic neuroendocine tumor. Cushing's syndrome is associated with severe morbidities and an increased mortality. The major systemic complications and the main cause of death are represented by cardiovascular disease. The prognosis of the disease is mainly affected by the difficulties in the diagnosis and treatment of the disease, which remain a considerable challenge.

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