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Review
. 2008 Feb;14(1):61-74.
doi: 10.1016/j.cardfail.2007.09.006.

Cytokines and myocardial dysfunction: state of the art

Ayman A El-Menyar  1
Affiliations
Review

Cytokines and myocardial dysfunction: state of the art

Ayman A El-Menyar. J Card Fail. 2008 Feb.

Abstract

Background: Myocardial dysfunction has been associated with inflammation and cytokine modulation.

Objectives: The study objective was to understand the role of cytokines in the pathophysiology and management of myocardial dysfunction.

Methods: Heart failure has been revisited with revision of the pertinent published articles in the Medline, Scopus, Cochrane Database of Systematic Reviews, and EBSCO Host research.

Results: For the proinflammatory cytokines, illumination of this important point requires further diagnostic and therapeutic investigations. Data on chronic heart failure are not so reassuring; therefore, patients with advanced heart failure should not be treated with anticytokines at this time.

Conclusion: Further studies are warranted to pave the way for introducing cytokine and immunomodulation therapy at the optimal and appropriate time.

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