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. 2008 Apr;145(4):700-6.
doi: 10.1016/j.ajo.2007.11.019. Epub 2008 Jan 28.

Clinically significant macular edema and survival in type 1 and type 2 diabetes

Flavio E Hirai  1 , Michael D Knudtson, Barbara E K Klein, Ronald Klein
Affiliations

Clinically significant macular edema and survival in type 1 and type 2 diabetes

Flavio E Hirai et al. Am J Ophthalmol. 2008 Apr.

Abstract

Purpose: To investigate the association of clinically significant macular edema (CSME) and long-term survival in individuals with type 1 and type 2 diabetes.

Design: Population-based cohort study.

Methods: The Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) is an ongoing prospective population-based cohort study initiated from August 21, 1980 through July 30, 1982 of individuals with diabetes diagnosed at either younger than 30 years of age (younger-onset group; n = 996) or 30 years of age or older (older-onset group; n = 1,370). Stereoscopic color retinal photographs were graded for retinopathy using the modified Airlie House classification scheme. CSME was defined by the Early Treatment Diabetic Retinopathy Study criteria.

Results: Prevalence of CSME was 5.9% and 7.5% for the younger- and older-onset groups, respectively. After 20 years of follow-up, 276 younger-onset and 1,197 older-onset persons died. When adjusting for age and gender, CSME was not significantly associated with all-cause mortality (hazard ratio [HR], 1.41; 95% confidence interval [CI], 0.96 to 2.07; P = .08) or ischemic heart disease mortality (HR, 1.14; 95% CI, 0.61 to 2.12; P = .68) in the younger-onset group. In the older-onset group, there was increased all-cause and ischemic heart disease mortality when CSME was present (HR, 1.55; 95% CI, 1.25 to 1.92; P < .01; and HR, 1.56; 95% CI, 1.15 to 2.13; P < .01, respectively), when adjusting for age and gender. After controlling for other risk factors, the association remained significant for ischemic heart disease (HR, 1.58; 95% CI, 1.07 to 2.35; P = .02) among those taking insulin. CSME was not significantly associated with stroke mortality in either group.

Conclusions: CSME seems to be a risk indicator for decreased survival in persons with older-onset diabetes mellitus. The presence of CSME may identify individuals who should be receiving care for detection and treatment of cardiovascular disease.

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Figures

Figure 1
Figure 1
Age- and sex-adjusted survival curves by clinically significant macular edema (CSME) status at baseline in younger-onset persons for all-cause and ischemic heart disease mortality.
Figure 2
Figure 2
Age- and sex-adjusted survival curves by clinically significant macular edema (CSME) status at baseline in older-onset persons NOT taking exogenous insulin for all-cause and ischemic heart disease mortality.
Figure 3
Figure 3
Age- and sex-adjusted survival curves by clinically significant macular edema (CSME) status at baseline in older-onset persons taking exogenous insulin for all-cause and ischemic heart disease mortality.
See this image and copyright information in PMC

References

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