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. 2008 Apr;52(4):1529-32.
doi: 10.1128/AAC.01097-07. Epub 2008 Jan 28.

In vitro interactions of micafungin with amphotericin B against clinical isolates of Candida spp

Carolina Serena  1 , Marçal Mariné, Guillermo Quindós, Alfonso J Carrillo, J F Cano, F Javier Pastor, Josep Guarro
Affiliations

In vitro interactions of micafungin with amphotericin B against clinical isolates of Candida spp

Carolina Serena et al. Antimicrob Agents Chemother. 2008 Apr.

Abstract

The in vitro activity of amphotericin B in combination with micafungin was evaluated against 115 isolates representing seven species of Candida. Overall, the percentages of synergistic interactions were 50% and 20% when the MIC-2 (lowest drug concentration to cause a prominent reduction in growth) and MIC-0 (lowest drug concentration to cause 100% growth inhibition) end point criteria, respectively, were used. Antagonism was not observed. Some of the interactions were confirmed by time-kill assays.

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Figures

FIG. 1.
FIG. 1.
Time-kill studies conducted at 1× MIC for C. albicans, C. parapsilosis, and C. glabrata. Synergistic interactions were observed for C. albicans FMR 9542 (A), C. parapsilosis FMR 9544 (C), and C. glabrata FMR 8489 (E), and indifferent interactions were observed for C. albicans FMR 9600 (B), C. parapsilosis FMR 9601 (D), and C. glabrata FMR 8498 (F).
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