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. 2008 Feb;12(2):225-7.

Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

M F Cotton  1 , H S Schaaf, G Lottering, H L Weber, J Coetzee, S Nachman; PACTG 1041 Team
Affiliations
  • PMID: 18230259

Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

M F Cotton et al. Int J Tuberc Lung Dis. 2008 Feb.

Abstract

Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, 95%CI 8.0-12.4) of 766 infants had contact with a TB source case. Nurses and lay counsellors identified 52 infants during pre-screening and doctors identified 25 during formal screening. High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure.

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