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Case Reports
. 2007 Fall;9(4):235-8.

Bilateral testicular infarction and orchiectomy as a complication of polyarteritis nodosa

Sean P Stroup  1 , Shannon R Herrera, Donald S Crain
Affiliations
Case Reports

Bilateral testicular infarction and orchiectomy as a complication of polyarteritis nodosa

Sean P Stroup et al. Rev Urol. 2007 Fall.

Abstract

We report an unusual case of a 28-year-old male with constitutional symptoms and bilateral testicular pain. After diagnosis of cytomegalovirus (CMV) hepatitis, his constitutional symptoms and testicular pain worsened despite treatment for epididymoorchitis. Ultrasound was concerning for infarction. Exploration in the operating room revealed bilateral testicular infarction requiring bilateral orchiectomy with subsequent androgen hormone replacement. Pathologic diagnosis was polyarteritis nodosa (PAN). PAN is a rare systemic vasculitis that affects multiple organs. There are no previous reports of PAN-induced vasculitis leading to bilateral testicular infarction and bilateral orchiectomy.

Keywords: Androgen replacement therapy; Polyarteritis nodosa; Testicular infarction.

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Figures

Figure 1
Figure 1
Gross photograph showing thrombosis of spermatic cord and testicular vessels with bilateral testicular infarction.
Figure 2
Figure 2
Low-power view showing vasculitis and thrombosis affecting a vessel within the spermatic cord (hematoxylin-eosin, original magnification × 40).
Figure 3
Figure 3
High-power view of inflammatory cells and thrombosis within the testicle, (hematoxylin-eosin, original magnification × 400).
See this image and copyright information in PMC

References

    1. Fraenkel-Rubin M, Ergas D, Sthoeger ZM. Limited polyarteritis nodosa of the male and female reproductive systems: diagnostic and therapeutic approach. Ann Rheum Dis. 2002;61:362–364. - PMC - PubMed
    1. Teichman JM, Mattrey RF, Demby AM, Schmidt JD. Polyarteritis nodosa presenting as acute orchitis: a case report and review of the literature. J Urol. 1993;149:1139–1140. - PubMed
    1. Lightfoot RW , Jr, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Arthritis Rheum. 1990;33:1088–1093. - PubMed
    1. Dahl EV, Baggenstoss AH, Deweerd JH. Testicular lesions of periarteritis nodosa, with special reference to diagnosis. Am J Med. 1960;28:222–228. - PubMed
    1. Susanto CR, Fedder G, Looijen-Salamon MG. Acute, painful, and swollen testicle as the presenting feature in polyarteritis nodosa. Eur J Intern Med. 2003;14:441–443. - PubMed

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