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Case Reports
. 2008 Jan;63(1):119-23.
doi: 10.1002/ana.21295.

Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Clement Hamani  1 , Mary Pat McAndrews, Melanie Cohn, Michael Oh, Dominik Zumsteg, Colin M Shapiro, Richard A Wennberg, Andres M Lozano
Affiliations
Case Reports

Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Clement Hamani et al. Ann Neurol. 2008 Jan.

Abstract

Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double-blinded "on" versus "off" manner demonstrated that stimulation increased recollection but not familiarity-based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions.

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