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Review
. 1991 Dec:32 Suppl 2:195-201.
doi: 10.1269/jrr.32.supplement2_195.

Radiation carcinogenesis in mouse skin and its threshold-like response

H Tanooka  1 , A Ootsuyama
Affiliations
Free article
Review

Radiation carcinogenesis in mouse skin and its threshold-like response

H Tanooka et al. J Radiat Res. 1991 Dec.
Free article

Abstract

Experiments on the dose-response of tumor development induced by repeated local beta irradiation of the back of mice are summarized. Results indicated a 100% tumor incidence on irradiation at 2.5-11.8 Gy per exposure (dose-saturation effect) and the threshold-like dose response at lower doses. The mechanism underlying these phenomena is discussed on the basis of the tissue-misrepair model, that is misrepair caused by repeated stimulation of cell growth after repeated tissue injury.

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