Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Mar;3(2):348-54.
doi: 10.2215/CJN.02870707. Epub 2008 Jan 30.

Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C

Alessandra Calábria Baxmann  1 , Marion Souza Ahmed, Natália Cristina Marques, Viviane Barcellos Menon, Aparecido Bernardo Pereira, Gianna Mastroianni Kirsztajn, Ita Pfeferman Heilberg
Affiliations

Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C

Alessandra Calábria Baxmann et al. Clin J Am Soc Nephrol. 2008 Mar.

Abstract

Background and objectives: For addressing the influence of muscle mass on serum and urinary creatinine and serum cystatin C, body composition was assessed by skinfold thickness measurement and bioelectrical impedance analyses.

Design, setting, participants, & measurements: A total of 170 healthy individuals (92 women, 78 men) were classified as sedentary or with mild or moderate/intense physical activity. Blood, 24-h urine samples, and 24-h food recall were obtained from all individuals.

Results: Serum and urinary creatinine correlated significantly with body weight, but the level of correlation with lean mass was even greater. There was no significant correlation between body weight and lean mass with cystatin C. Individuals with moderate/intense physical activity presented significantly lower mean body mass index (23.1 +/- 2.5 versus 25.7 +/- 3.9 kg/m(2)) and higher lean mass (55.3 +/- 10.0 versus 48.5 +/- 10.4%), serum creatinine (1.04 +/- 0.12 versus 0.95 +/- 0.17 mg/dl), urinary creatinine (1437 +/- 471 versus 1231 +/- 430 mg/24 h), protein intake (1.4 +/- 0.6 versus 1.1 +/- 0.6 g/kg per d), and meat intake (0.7 +/- 0.3 versus 0.5 +/- 0.4 g/kg per d) than the sedentary individuals. Conversely, mean serum cystatin did not differ between these two groups. A multivariate analysis of covariance showed that lean mass was significantly related to serum and urinary creatinine but not with cystatin, even after adjustment for protein/meat intake and physical activity.

Conclusions: Cystatin C may represent a more adequate alternative to assess renal function in individuals with higher muscle mass when mild kidney impairment is suspected.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Correlation between fat-free mass, BCM, and body weight and urinary and serum creatinine.
Figure 2.
Figure 2.
Correlation between fat-free mass, BCM, and body weight and serum cystatin.
See this image and copyright information in PMC

References

    1. Perrone RD, Madias NE, Levey AS: Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 38: 1933–1953, 1992 - PubMed
    1. Lawson N, Lang T, Broughton A, Prinsloo P, Turner C, Marenah C: Creatinine assays: Time for action? Ann Clin Biochem 39: 599–602, 2002 - PubMed
    1. Shemesh O, Golbetz H, Kriss JP, Myers BD: Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 28: 830–838, 1985 - PubMed
    1. Goldberg TH, Finkelstein MS: Difficulties in estimating glomerular filtration rate in the elderly. Arch Intern Med 147: 1430–1433, 1987 - PubMed
    1. Bostom AG, Kronenberg F, Ritz E: Predictive performance of renal function equations for patients with chronic kidney disease and normal serum creatinine levels. J Am Soc Nephrol 13: 2140–2144, 2002 - PubMed

Publication types