Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2008 May;41(4):289-300.
doi: 10.1002/eat.20509.

The genetics of anorexia nervosa collaborative study: methods and sample description

Walter H Kaye  1 , Cynthia M Bulik, Katherine Plotnicov, Laura Thornton, Bernie Devlin, Manfred M Fichter, Janet Treasure, Allan Kaplan, D Blake Woodside, Craig L Johnson, Katherine Halmi, Harry A Brandt, Steve Crawford, James E Mitchell, Michael Strober, Wade Berrettini, Ian Jones
Affiliations
Multicenter Study

The genetics of anorexia nervosa collaborative study: methods and sample description

Walter H Kaye et al. Int J Eat Disord. 2008 May.

Abstract

Objective: Supported by National Institute of Mental Health (NIMH), this 12-site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN).

Method: Four hundred families will be ascertained with two or more individuals affected with AN. The assessment battery produces a rich set of phenotypes comprising eating disorder diagnoses and psychological and personality features known to be associated with vulnerability to eating disorders.

Results: We report attributes of the first 200 families, comprising 200 probands and 232 affected relatives.

Conclusion: These results provide context for the genotyping of the first 200 families by the Center for Inherited Disease Research. We will analyze our first 200 families for linkage, complete recruitment of roughly 400 families, and then perform final linkage analyses on the complete cohort. DNA, genotypes, and phenotypes will form a national eating disorder repository maintained by NIMH and available to qualified investigators.

PubMed Disclaimer

References

    1. Berkman N, Bulik C, Brownley K, Lohr K, Sedway J, Rooks A, et al. Management of Eating Disorders. Rockville, MD: Apr, 2006. Evidence Report/Technology Assessment No. 135. AHRQ Publication No. 06-E010. (Prepared by the RTI International-University of North Carolina Evidence-Based Practice Center under Contract No. 290-02-0016.) - PMC - PubMed
    1. Herzog D, Dorer D, Keel P, Selwyn S, Ekeblad E, Flores A, et al. Recovery and relapse in anorexia and bulimia nervosa: A 7.5-year follow-up study. J Am Acad Child Adolesc Psychiatry. 1999;38:829–837. - PubMed
    1. Herzog D, Nussbaum K, Marmor A. Comorbidity and outcome in eating disorders. Psychiatr Clin North Am. 1996;19:843–859. - PubMed
    1. Steinhausen H. The outcome of anorexia nervosa in the 20th century. Am J Psychiatry. 2002;159:1284–1293. - PubMed
    1. Sullivan PF. Mortality in anorexia nervosa. Am J Psychiatry. 1995;152:1073–1074. - PubMed

Publication types

LinkOut - more resources