[Inactivation of stem cells by allogenic lymphocytes: competition between T1- and T2-subpopulations]
- PMID: 18238
[Inactivation of stem cells by allogenic lymphocytes: competition between T1- and T2-subpopulations]
Abstract
Transplantation of the bone marrow cells with allogeneic T-lymphocytes to the irradiated hosts was accompanied by inactivation of the stem elements of the graft. The lymph node cells of T-mice (those deprived of B cells) were more active than the spleen cells of these mice. The stem cells inactivation was weakly expressed or absent in case of a combined acti-n of T-cells from the lymph nodes and the spleen.