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. 1991 Oct-Dec;35(4):255-9.

Treatment of neuroblastoma with [125I]metaiodobenzylguanidine

J C Sisson  1 , B Shapiro, R J Hutchinson, K R Zasadny, S Mallette, E E Mudgett, D M Wieland
Affiliations
  • PMID: 1823830

Treatment of neuroblastoma with [125I]metaiodobenzylguanidine

J C Sisson et al. J Nucl Biol Med (1991). 1991 Oct-Dec.

Abstract

To find a treatment that may be effective against micrometastases of advanced, stage III or IV neuroblastoma, [125I]metaiodobenzylguanidine (125I-MIBG) was used in a phase I toxicity trial. In seven patients, thrombocytopenia was encountered with absorbed whole body doses of 85-135 rad from 125I-MIBG, but the dosimetry was imprecise in predicting bone marrow injury. Three patients survived for over one year, results that may indicate efficacy of 125I-MIBG therapy.

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