Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Oct-Dec;16(4):257-60.
doi: 10.1007/BF03189969.

Metabolism of carvedilol in man

G Neugebauer  1 , P Neubert
Affiliations

Metabolism of carvedilol in man

G Neugebauer et al. Eur J Drug Metab Pharmacokinet. 1991 Oct-Dec.

Abstract

The metabolism of carvedilol was investigated in plasma and urine of 3 healthy male volunteers after administration of 50 mg of [14C]-labelled drug. Rapid and extensive biotransformation occurred. After 1.5 h 9% of total radioactivity in plasma consisted of unchanged drug, 22% of carvedilol-glucuronide and another 20% of oxidative cleavage products of the beta-blocking side chain. Urinary excretion of radioactivity amounted to 16% of which 2% represented unchanged drug, 32% carvedilol-glucuronide and about 25% side chain oxidation products. Ring-hydroxylated metabolites of carvedilol accounted for 18% of the radioactive compounds in the urine.

PubMed Disclaimer

References

    1. Clin Pharmacol Ther. 1986 Jun;39(6):677-82 - PubMed
    1. Eur J Clin Pharmacol. 1987;33(5):511-3 - PubMed

LinkOut - more resources