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. 2008 Mar;39(3):1039-41.
doi: 10.1161/STROKEAHA.107.499475. Epub 2008 Jan 31.

Prevalence and prognosis of coexistent asymptomatic intracranial stenosis

Fadi Nahab, George Cotsonis, Michael Lynn, Edward Feldmann, Seemant Chaturvedi, J Claude Hemphill, Richard Zweifler, Karen Johnston, David Bonovich, Scott Kasner, Marc Chimowitz; WASID Study Group

Prevalence and prognosis of coexistent asymptomatic intracranial stenosis

Fadi Nahab et al. Stroke. 2008 Mar.

Abstract

Background and purpose: There are limited data on the prevalence and prognosis of asymptomatic intracranial stenosis (AIS).

Methods: Baseline cerebral angiograms and MR angiograms were used to determine AIS (50% to 99%) coexistent to symptomatic intracranial stenosis for patients enrolled in the Warfarin-Aspirin Symptomatic Intracranial Disease study.

Results: Coexisting AIS were detected in 18.9% (n=14/74) of patients undergoing 4-vessel cerebral angiography and 27.3% (n=65/238) of patients undergoing MR angiogram. During a mean follow-up period of 1.8 years, no ischemic strokes were attributable to an AIS on cerebral angiography and 5 ischemic strokes (5.9%, 95% CI: 2.1% to 12.3%) occurred in the AIS territory on MR angiogram (risk at 1 year=3.5%, 95% CI: 0.8% to 9.0%).

Conclusions: Whereas the prevalence of coexisting AIS (50% to 99%) in patients with symptomatic stenosis is high, the risk of stroke from these asymptomatic stenoses is low.

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